Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

…, HB Cottam, M Sen, LM Leoni… - Proceedings of the …, 2004 - National Acad Sciences
B cell chronic lymphocytic leukemia (CLL) is characterized by an accumulation of mature,
functionally incompetent B cells. Wnts are a large family of secreted glycoproteins involved in …

Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents

LM Leoni, B Bailey, J Reifert, HH Bendall, RW Zeller… - Clinical cancer …, 2008 - AACR
Purpose: Bendamustine has shown clinical activity in patients with disease refractory to
conventional alkylator chemotherapy. The purpose of this study was to characterize the …

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

…, T Hayashi, L Leider-Trejo, J Lee, LM Leoni… - Gastroenterology, 2002 - Elsevier
BACKGROUND & AIMS: Impaired mucosal barrier, cytokine imbalancE. and dysregulated
CD4 + T cells play important roles in the pathogenesis of experimental colitis and human …

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

IM Pedersen, S Kitada, LM Leoni… - Blood, The Journal …, 2002 - ashpublications.org
Chronic lymphocytic leukemia (CLL) B cells have defects in apoptosis pathways and therefore
accumulate in vivo. However, when removed from the patient and cultured in vitro, these …

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

…, HB Cottam, DA Carson, LM Leoni - Blood, The Journal …, 2000 - ashpublications.org
Adenine deoxynucleosides induce apoptosis in quiescent lymphocytes and are thus useful
drugs for the treatment of indolent lymphoproliferative diseases. To explain why …

A new reporter cell line to monitor HIV infection and drug susceptibility in vitro

A Gervaix, D West, LM Leoni… - Proceedings of the …, 1997 - National Acad Sciences
Determination of HIV infectivity in vitro and its inhibition by antiretroviral drugs by monitoring
reduction of production of p24 antigen is expensive and time consuming. Such assays also …

Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas

CS Rhee, M Sen, D Lu, C Wu, L Leoni, J Rubin, M Corr… - Oncogene, 2002 - nature.com
The diverse receptor-ligand pairs of the Wnt and frizzled (Fz) families play important roles
during embryonic development, and thus may be overexpressed in cancers that arise from …

Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor α

Q Chao, L Deng, H Shih, LM Leoni… - Journal of medicinal …, 1999 - ACS Publications
A series of isoquinolin-1-ones and quinazolin-4-ones and related derivatives were prepared
and evaluated for their ability to inhibit tumor necrosis factor α (TNFα) production in human …

Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells

LM Leoni, E Hamel, D Genini, H Shih… - Journal of the …, 2000 - academic.oup.com
BACKGROUND: Certain antimitotic drugs have antitumor activities that apparently result from
interactions with nontubulin components involved in cell growth and/or apoptotic cell death…

[HTML][HTML] Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor …

SR Hustinx, LM Leoni, CJ Yeo, PN Brown, M Goggins… - Modern pathology, 2005 - Elsevier
The p16INK4A/CDKN2A (p16) gene on chromosome 9p21 is inactivated in >90% of
invasive pancreatic cancers. In 40% of pancreatic cancers the p16 gene is inactivated by …