Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in
preschool children with cystic fibrosis (CF), but its utility to identify and manage these events in …

The lung clearance index (LCI) measured by the multiple breath washout (MBW) test is
sensitive to early lung disease in children with cystic fibrosis. While LCI worsens during the …

The PROSPECT study, a post-approval observational study in the US, showed no significant
changes in lung function as measured by spirometry with clinical initiation of lumacaftor/…

Introduction While antibiotic eradication therapy (AET) of early Pseudomonas aeruginosa
infection is considered standard of care, its long-term effect on the subsequent course of cystic …

Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
are CF-causing. CFTR modulators target variants to improve lung function, but marked …

The gut microbiome plays a vital role in health and wellbeing of animals, and an increasing
number of studies are investigating microbiome changes in wild and managed populations …

Despite being the fourth largest criminal market in the world, no forensic tools have been
sufficiently developed to accurately determine the legal status of seized animals and their parts. …

Background Antibiotics are often changed during treatment of pulmonary exacerbations (PEx)
in people with cystic fibrosis (CF) who have a poor clinical response. We aimed to …

Rationale: Cardiopulmonary exercise testing (CPET) provides prognostic information in cystic
fibrosis (CF); however, its prognostic value for patients with advanced CF lung disease is …

Background The multiple breath washout (MBW) test may be most useful in tracking disease
progression over time to inform treatment decisions. In the clinical setting, alternative …