Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application of …

In environmental magnetism, rock and mineral magnetic techniques are used to investigate
the formation, transportation, deposition, and postdepositional alterations of magnetic …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some
cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here…

The mammalian target of rapamycin (mTOR) kinase is the catalytic subunit of two functionally
distinct complexes, mTORC1 and mTORC2, that coordinately promote cell growth, …

In this paper we study the stabilization of both continuous-time and discrete-time linear
systems with both state and input delays. Extended observer based controllers are designed to …

Protein kinases are a large family of approximately 530 highly conserved enzymes that
transfer a γ-phosphate group from ATP to a variety of amino acid residues, such as tyrosine, …

Combined analyses of deep tow magnetic anomalies and International Ocean Discovery
Program Expedition 349 cores show that initial seafloor spreading started around 33 Ma in the …

Impairment of working memory is one of the most important deleterious effects of marijuana
intoxication in humans, but its underlying mechanisms are presently unknown. Here, we …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb
Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. …